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Differentiation of Secreted and Membrane-Type Matrix Metalloproteinase Activities Based on Substitutions and Interruptions of Triple-Helical Sequences †

✍ Scribed by Minond, Dmitriy; Lauer-Fields, Janelle L.; Cudic, Mare; Overall, Christopher M.; Pei, Duanqing; Brew, Keith; Moss, Marcia L.; Fields, Gregg B.

Book ID
126790616
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
159 KB
Volume
46
Category
Article
ISSN
0006-2960

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Type II tropocollagen molecules were reacted with matrix metalloproteinase 8 (MMP-8) and the binding sites as well as the cleavage site of MMP-8 were detected on individual molecules using atomic force microscopy (AFM). Approximately 300-nm-long coiledcoil tropocollagen molecules were straightened a