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Differentiation of human prostate cancer from benign hypertrophy by in vitro1H NMR

✍ Scribed by A. H. Fowler; A. A. Pappas; J. C. Holder; A. E. Finkbeiner; G. V. Dalrymple; M. S. Mullins; J. R. Sprigg; R. A. Komoroski

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 443 KB
Volume: 25
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910250114

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✦ Synopsis

Abstract

In vitro ^1^H NMR spectra were acquired for perchloric acid extracts of tissue samples ofhuman prostate. Seven patients were diagnosed with prostate cancer, 13 with benign prostatic hypertrophy, and 3 with both conditions. Statistically significant differences between the cancer and benign groups were seen for the metabolite peak arearatios of citrate, creatine, and phosphorylcholine to alanine. and citrate to glutamate. There was no correlation of Gleason grade with any of the ratios measured for the cancer samples. Spectra from different sections of large tumors often yielded substantially different area ratios. confirming the heterogeneous nature of these prostate tumors.

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