Differentiation of germ cells in seminiferous tubules transplanted to testes of germ cell-deficient mice of W/Wv and SI/SId genotypes

✍ Scribed by Hideya Kuroda; Hiroki Nakayama; Mikio Namiki; Keishi Matsumoto; Yoshitake Nishimune; Yukihiko Kitamura

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 966 KB
• Volume: 139
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1041390215

✦ Synopsis

C57BL/6)F,-Sl/Sld (hereafter, WCB6F,-Sl/Sld) mice are sterile due to the deficient spermatogenesis in the testes. The cause of deficient spermatogenesis in WBB6FI-W/W mice is considered to be a defect in germ cells themselves, whereas that in WCB6FI-Sl/Sld mice is considered to be a defect in tissue environment necessary for differentiation of germ cells. Seminiferous tubules isolated from cryptorchid testes of C57BL/6-+ / + mice were transplanted into the testes of W B B ~F I -W I W and WCB6FI-Sl/Sld mice to clarify that the extratubular environment of these mice was intact or not. Type A spermatogonia in the transplanted tubules normally differentiated into spermatids, suggesting that the extratubular environment is intact in both WBB6F1-W/W and WCB6F,-SI/Sld mice.