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Differentiation in dystrophic muscle cultures from mice of different ages

✍ Scribed by Paul S. Bryers; Marion S. Ecob

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
437 KB
Volume
7
Category
Article
ISSN
0148-639X

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✦ Synopsis

Abstract

Muscle from dystrophic (129 ReJ dy/dy) mice, aged 1, 2, 3, 4, and 6 months, was cocultured with normal embryonic mouse spinal cord. Cultures were scored for regeneration (myotubes) and differentiation (cross‐striated or contracting fibers) over a 28‐day period. Although muscle from dystrophic mice of all ages was able to regenerate, the ability to differentiate decreased with the increasing age of the mouse. Muscle from litter‐mate control mice of different ages regenerated and differentiated equally well.

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