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Differentiation-dependent expression of signal transducers and activators of transcription (STATs) might modify responses to growth factors in the cancers of the head and neck

โœ Scribed by Istvan Arany; San-H. Chen; Judit K. Megyesi; Karen Adler-Storthz; Z. Chen; Srinivasan Rajaraman; Istvan A. Ember; Stephen K. Tyring; Miriam M. Brysk

Book ID
117467885
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
220 KB
Volume
199
Category
Article
ISSN
0304-3835

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The transcription factors signal transdu
The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression
โœ Ji Hoon Yu; Bing-Mei Zhu; Mark Wickre; Gregory Riedlinger; Weiping Chen; Atsushi ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 841 KB

Although the cytokine-inducible transcription factor signal transducer and activator of transcription 5 (STAT5) promotes proliferation of a wide range of cell types, there are cell-specific and context-specific cases in which loss of STAT5 results in enhanced cell proliferation. Here, we report that