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Differentiation and the tumorigenic and metastatic phenotype of murine melanoma cells

✍ Scribed by Koichiro Kameyama; Wilfred D. Vieira; Katsuhiko Tsukamoto; Lloyd W. Law; Vincent J. Hearing

Book ID
102865343
Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
987 KB
Volume
45
Category
Article
ISSN
0020-7136

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✦ Synopsis

Using 816 FIO murine melanoma cells and sublines generated from the JBlMS melanoma which exhibit various degrees of melanogenesis, the relationships among differentiation, tumorigenicity, and metastatic potential were examined. The effect of melanocyte-stimulating hormone (MSH), which specifically stimulates differentiation of melanocytes, was also studied. All melanoma lines tested were capable of growing as experimental pulmonary metastases but, surpris-

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