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Differentiation and apoptosis of neuroblastoma cells: Role of N-myc gene product

โœ Scribed by Umberto Galderisi; Giovanni Di Bernardo; Marilena Cipollaro; Gianfranco Peluso; Antonino Cascino; Roberto Cotrufo; Mariarosa A.B. Melone

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
216 KB
Volume
73
Category
Article
ISSN
0730-2312

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โœฆ Synopsis

To clarify the role and function of the N-myc product in cell differentiation and apoptosis, we used the antisense oligonucleotide technique to inhibit N-myc gene expression in neuroblastoma cells with different phenotypes: intermediate (I) and neuronal (N), or Schwann-glia (S), respectively. The results suggest that N-myc operates along different pathways. Inhibiting N-myc gene expression either results in suppression of cell proliferation or in induction of differentiation and/or apoptosis.

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