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Differentiating role of B7-CD28/CTLA-4 interaction in the induction of mucosal inflammation and regulatory T cell functions in chronic experimental colitis

✍ Scribed by Zhanju Liu; Univ Hosp Gasthuisberg; Philippe Maerten; Stefaan Colpaert; Jan L. Ceuppens; Karel Geboes; Paul Rutgeerts


Book ID
119429097
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
367 KB
Volume
120
Category
Article
ISSN
0016-5085

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Role of interleukin-12 in the induction
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IL-12 promotes Th1 cell differentiation and cell-mediated immunity. In the present study, the potential role of IL-12 was analyzed in an experimental colitis model in scid mice reconstituted with syngeneic CD45RB high CD4 + T cells. Real-time reverse transcription-PCR studies demonstrated that IL-12