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Differentiating human leukemia cells express heparanase that degrades heparan sulfate in subendothelial extracellular matrix

✍ Scribed by Joachim Yahalom; Eitan Fibach; Ruth Bar-Tana; ZVI Fuks; Israel Vlodavsky


Book ID
113238940
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
680 KB
Volume
12
Category
Article
ISSN
0145-2126

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Sequential degradation of heparan sulfat
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## Abstract A highly metastatic variant (ESb) of a methylchol‐anthrene‐induced T lymphoma elaborates a heparan sulfate (HS) degrading endoglycosidase (heparanase) to a much higher extent than its non‐metastatic parental subline (Eb). Whereas a serum‐free medium conditioned by either subline contain