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Differential stimulation of signaling pathways initiated by Edg-2 in response to lysophosphatidic acid or sphingosine-1-phosphate

✍ Scribed by O. Peyruchaud; D. F. Mosher


Publisher
Springer
Year
2000
Tongue
English
Weight
570 KB
Volume
57
Category
Article
ISSN
1420-682X

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In Xenopus oocytes, both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) activate Ca2+-dependent oscillatory Cl- currents by acting through membrane-bound receptors. External application of 50 microM S1P elicited a long-lasting oscillatory current that continued over 30 min from the be