## Abstract Prostateβspecific antigen (PSA) is a widely used marker for prostate cancer. In the literature, there are reports of nonprostatic expression of PSA that potentially can affect early diagnosis. However, the results are scattered and inconclusive, which motivated us to conduct a more comp
Differential steroid hormone regulation of human glandular kallikrein (hK2) and prostate-specific antigen (PSA) in breast cancer cell lines
β Scribed by Angeliki Magklara; Linda Grass; Eleftherios P. Diamandis
- Book ID
- 110234049
- Publisher
- Springer US
- Year
- 2000
- Tongue
- English
- Weight
- 115 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0167-6806
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## BACKGROUND. Human prostate-specific antigen (PSA) and human kallikrein 2 (hK2) are expressed primarily by prostate epithelial cells. PSA and hK2 both exist as free protein and complexed with protease inhibitors (e.g., β£1-antichymotrypsin, ACT) in serum. The expression of PSA and hK2 in LNCaP ce
## Abstract Accumulating evidence indicates that androgens and the androgen receptor modulate the development and progression of breast adenocarcinoma; however, the precise role and actions remain poorly defined. We examined previously the steroid hormone regulation of 2 known androgenβregulated ka