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Differential sensitivity of organic anion transporters in rat renal brush-border membrane to diethyl pyrocarbonate

✍ Scribed by Mikihisa Takano; Junya Nagai; Tomonobu Okano; Kiyoshi Hirozane; Masato Yasuhara; Ryohei Hori

Book ID
115730745
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
648 KB
Volume
1192
Category
Article
ISSN
0005-2736

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Lack of renal secretion of carbenicillin
Lack of renal secretion of carbenicillin in rats: poor affinity to the organic anion transporter at renal brush border membrane
✍ Tomoo Itoh; Shin-ichi Koyano; Hiromi Nakaura; Yasuyuki Tsuda; Hideo Yamada πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 206 KB πŸ‘ 2 views

The renal secretion of carbenicillin (CBPC) was studied in rats. The results obtained in the in vivo study indicated very poor renal secretion of CBPC in rats, which was entirely different from those observed in humans and rabbits. In humans and rabbits, significant and stereoselective renal secreti