Differential sensitivity of cardiac K(ATP)+channels to guanine nucleotides — evidence for a heterogeneous channel population

✍ Scribed by I. Benz; M. Kohlhardt

• Publisher: Springer
• Year: 1992
• Tongue: English
• Weight: 270 KB
• Volume: 21
• Category: Article
• ISSN: 1432-1017
• DOI: 10.1007/bf00185124

✦ Synopsis

In cell-free patches from cultured neonatal rat cardiocytes, the cytosolic presence of GTP-gamma-S (100 mumol/l) or GDP-beta-S (100 mumol/l) activated K+(ATP) channels. GTP-gamma-S required cytosolic Mg++, suggesting that an activated G-protein causes the increase in open probability. The great variations of the channel response to GTP-gamma-S and GDP-beta-S indicates that cardiac K+(ATP) channels represent a heterogeneous family.