Differential selectivity of CIITA promoter activation by IFN-γ and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-α

IFN-γ-induced BACE1 expression is mediat

IFN-γ-induced BACE1 expression is mediated by activation of JAK2 and ERK1/2 signaling pathways and direct binding of STAT1 to BACE1 promoter in astrocytes

✍ Hyun Jin Cho; Su-Kyoung Kim; Seok Min Jin; Eun-Mi Hwang; Yong Sik Kim; Kyoon Huh 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 625 KB

## Abstract β‐Site APP cleaving enzyme 1 (BACE1) is an essential enzyme for the production of β amyloid. Since we found that injection of interferon‐γ (IFN‐γ) into young mouse brains increased BACE1 expression in astrocytes, we investigated molecular mechanisms underlying this process by cloning a