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Differential roles of signal transduction pathways for platelet-derived growth factor-induced proliferation and migration of rat pancreatic stellate cells

✍ Scribed by Masamune, Atsushi; Kikuta, Kazuhiro; Satoh, Masahiro; Kume, Kiyoshi; Shimosegawa, Tooru


Book ID
123488022
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
238 KB
Volume
124
Category
Article
ISSN
0016-5085

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Platelet-derived growth factor (PDGF) is the most potent mitogen for hepatic stellate cells (HSCs) in vitro. The aim of this study was to investigate the role of the lipid-derived second messenger phosphatidic acid (PA) in mediating this effect and, in particular, to determine its interaction with t