Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phenylephrine-induced cardiac myocyte hypertrophy

Involvement of both extracellular signal

Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate–induced upregulation of p21Cip1 in colon cancer cells

✍ Shyr-Yi Lin; Yu-Chih Liang; Yuan-Soon Ho; Shu-Huei Tsai; Shiann Pan; Wen-Sen Lee 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB

## Abstract Protein kinase C (PKC), a family of serine‐threonine kinases, has been implicated in the regulation of colon tumorigenesis. However, the specific isoform of PKC involved in this process is not clear. In the present study, we found that treatment of the cultured human colon cancer cell l