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Differential role of four cysteines on the activity of a low Mr phosphotyrosine protein phosphatase

✍ Scribed by Paola Chiarugi; Riccardo Marzocchini; Giovanni Raugei; Claudia Pazzagli; Andrea Berti; Guido Camici; Gianpaolo Manao; Gianni Cappugi; Giampietro Ramponi


Book ID
115926809
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
321 KB
Volume
310
Category
Article
ISSN
0014-5793

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The oxidation state of the cysteine residue at the active site of human protein tyrosine phosphatase (PTP-1B) greatly affects its enzymatic activity. We wished to examine peroxide-treated preparations for modifications of this enzyme with electrospray mass spectrometry in order to determine the loca