𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Differential responses to growth factors by normal human mesothelial cultures from individual donors

✍ Scribed by John F. Lechner; Moira A. LaVeck; Brenda I. Gerwin; Elizabeth A. Matis

Book ID
102880908
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
594 KB
Volume
139
Category
Article
ISSN
0021-9541

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✦ Synopsis

A significant interindividual variation in the growth rates is found in normal cultured human mesothelial (NHM) cells derived from different donors. This variation is observed when the mesothelial cells are incubated in medium containing serum and when the potencies of several separate growth factors are measured by using defined media. Depending on the donor, gamma-interferon and interleukin-2 can be toxic, have no effect, or stimulate the growth rate of N H M cells. Cultured N H M cells can be induced to multiply by growth factors that are released by activated macrophages. Thus, interindividual variation in NHM cell growth control could play a role in the pathogenesis of mesothelioma for a person exposed to asbestos.

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