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Differential Responses of Msh2/6 and Damaged DNA Probed by Molecular Dynamics

✍ Scribed by Salsbury, Freddie R.; Negureanu, Lacramioara

Book ID: 123400298
Publisher: Biophysical Society
Year: 2014
Tongue: English
Weight: 90 KB
Volume: 106
Category: Article
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.3647

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## Abstract A systematic search by Southern blot analysis in a cohort of 439 hereditary nonpolyposis colorectal cancer (HNPCC) families for genomic rearrangements in the main mismatch repair (MMR) genes, namely, __MSH2__, __MLH1__, __MSH6__, and __PMS2__, identified 48 genomic rearrangements causat