Differential requirement for accessory cells in polyclonal T-cell activation
β Scribed by Mohan L. Sopori; Yvonne L. Hurt; Susamma Cherian; Alan M. Kaplan; Tiber Diamantstein
- Book ID
- 113133814
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 964 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0008-8749
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Highly purified murine lymph node T cells were used to test the hypothesis that polyclonal T cell activation requires the recognition of mitogen-modified major histocompatibility complex (MHC) antigens on accessory cells (AC) by the T cells. A variety of tumor cells lines, including macrophage, B an
It has previously been reported (Hiinig, T. et al., Eur. J. Zmmunol. 1983. 13: 1) that highly purified peripheral T cells do not respond to concanavalin A (Con A) even in the presence of Con A-induced spleen cell supernatant as a source of interleukin 2 (IL 2). In the present report, the hypothesis