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Differential Regulation of Muscarinic Cholinergic Receptors in Human Heart Failure and Reverse Remodelling

✍ Scribed by Moravec, Christine S.; Sweet, Wendy E.; French, Jessica A.; Schneeberger, Dana L.; McKee, Michael G.; Tang, W.H. Wilson; Starling, Randall C.


Book ID
122746766
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
163 KB
Volume
19
Category
Article
ISSN
1532-8414

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In end-stage heart failure the expression of different myocardial regulatory proteins involved in the beta-adrenergic cAMP signalling pathway is altered. The downregulation of beta 1-adrenoceptors and their uncoupling from the effector as well as an increased expression of the inhibitory GTP-binding