Epigenetic regulation of human telomeras
โ
Liang Liu; Sabita N. Saldanha; Mitchell S. Pate; Lucy G. Andrews; Trygve O. Toll
๐
Article
๐
2004
๐
John Wiley and Sons
๐
English
โ 1016 KB
The human telomerase reverse transcriptase (TERT) gene is transcriptionally inactivated in most differentiated cells but is reactivated in the majority of cancer cells. To elucidate how TERT is inactivated during differentiation, we applied all-trans retinoic acid (ATRA) to induce the differentiatio