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Differential regulation of iron chelator-induced IL-8 synthesis via MAP kinase and NF-κB in immortalized and malignant oral keratinocytes

✍ Scribed by Hwa-Jeong Lee; Jun Lee; Sun-Kyung Lee; Suk-Keun Lee; Eun-Cheol Kim

Book ID: 115011049
Publisher: BioMed Central
Year: 2007
Tongue: English
Weight: 804 KB
Volume: 7
Category: Article
ISSN: 1471-2407
DOI: 10.1186/1471-2407-7-176

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## Abstract We have shown that the bacterial iron chelator, deferoxamine (DFO), triggers inflammatory signals including the production of CXC chemokine IL‐8, in human intestinal epithelial cells (IECs) by activating the ERK1/2 and p38 kinase pathways. In this study we investigated the mechanisms in