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Differential regulation of insulin receptor substrate-1 degradation during mannitol and okadaic acid induced apoptosis in human neuroblastoma cells

✍ Scribed by Bhumsoo Kim; SangSu Oh; Cynthia M. van Golen; Eva L. Feldman


Book ID
113527720
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
318 KB
Volume
17
Category
Article
ISSN
0898-6568

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## Abstract __N__‐(4‐hydroxyphenyl)retinamide (4HPR, fenretinide), a retinoic acid (RA) derivative and a potential cancer preventive agent, is known to exert its chemotherapeutic effects in cancer cells through induction of apoptosis. Earlier work from our laboratory has shown that relatively low c