Differential regulation of glycosaminoglycan, fibronectin, and collagenase production in cultured human dermal fibroblasts by interferon-alpha,-beta, and-gamma

Uncoordinate regulation of collagenase,

Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostaglandin E2: Selective enhancement of collagenase gene expression in human dermal fibroblasts in culture

✍ Alain Mauviel; Cynthia Halcin; Panayiotis Vasiloudes; William C. Parks; Markku K 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 838 KB

The degradative effects of interleukin-1 (IL-1) on the extracellular matrix of connective tissue are mediated primarily by metalloproteinases and prostaglandins. Clinical observations suggest that these effects can be prevented, to some extent, by the use of non-steroidal anti-inflammatory drugs. We