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Differential regulation of cytokine and chemokine production in lipopolysaccharide-induced tolerance and priming

✍ Scribed by Octavia M Peck; David L Williams; Kevin F Breuel; John H Kalbfleisch; Hongkuan Fan; George E Tempel; Giuseppe Teti; James A Cook

Book ID: 116397425
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 231 KB
Volume: 26
Category: Article
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2004.02.011

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Bacterial lipopolysaccharide (LPS) has been shown to induce a wide variety of proinflammatory cytokines and chemokines. An initial challenge with minute amounts of LPS causes tolerance to later LPS effects which is characterized by a much lower or abrogated release of pro-inflammatory cytokines. To