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Differential regulation of cyclooxygenase-2 in the rat hippocampus after cerebral ischemia and ischemic tolerance

✍ Scribed by Jeong-Sun Choi; Ha-Young Kim; Myung-Hoon Chun; Jin-Woong Chung; Mun-Yong Lee

Book ID
116768183
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
495 KB
Volume
393
Category
Article
ISSN
0304-3940

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## Abstract Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)‐2, the principal isoenzyme in the brain, modulates inflammation, glutamate‐mediated cytotoxicity, and synaptic plasticity. We demonstrated that delayed treatment with differen