Critical role of poly(ADP-ribose) polyme
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Young-Ok Son; Sung-Ho Kook; Yong-Suk Jang; Xianglin Shi; Jeong-Chae Lee
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Article
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2009
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John Wiley and Sons
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English
⚖ 399 KB
👁 2 views
## Abstract Continuously generated hydrogen peroxide (H~2~O~2~) inhibits typical apoptosis and instead initiates a caspase‐independent, apoptosis‐inducing factor (AIF)‐mediated pyknotic cell death. This may be related to H~2~O~2~‐mediated DNA damage and subsequent ATP depletion, although the exact