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Differential regulation of C-terminal splice variants of the glutamate transporter GLT-1 by tumor necrosis factor-alpha in primary cultures of astrocytes

✍ Scribed by Marylène C. Focant; Stéphanie Goursaud; Yannick Nizet; Emmanuel Hermans

Book ID
116765666
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
788 KB
Volume
58
Category
Article
ISSN
0197-0186

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## Abstract Defective glutamate uptake has been implicated as a pathogenic event of neuronal damage related to cerebral ischemia and hypoxia. In several models of ischemia‐hypoxia, a reduced immunoreactivity and altered RNA expression of excitatory amino acid transporter 2 (EAAT2), the major excita