Differential recognition of structural details of bacterial lipopeptides by toll-like receptors
✍ Scribed by Michael Morr; Osamu Takeuchi; Shizuo Akira; Markus M. Simon; Peter F. Mühlradt
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 298 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Toll‐like receptor 2 (TLR2) is a pattern recognition receptor that plays an important role in enabling cells of the innate immune system to recognize conserved structural motifs on a wide array of pathogens including gram‐positive bacteria. Although microglia have recently been shown to
## Abstract Lipopeptides, a form of peptide immunogens, are currently under intense investigation as human vaccines for many infectious pathogens and cancers. However, the cellular and molecular mechanisms of lipopeptide immunogenicity are only partially understood. We have investigated the influen