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Differential Rate and Potassium-Dependent Effects of the Class III Agents d-Sotalol and Dofetilide on Guinea Pig Papillary Muscle

✍ Scribed by Harald Marschang; Thorsten Beyer; Laszlo Karolyi; Wolfgang Kübler; Johannes Brachmann


Book ID
110254055
Publisher
Springer US
Year
1998
Tongue
English
Weight
279 KB
Volume
12
Category
Article
ISSN
0920-3206

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✍ Tao Yang; Pål M. Tande; David A. Lathrop; Helge Refsum 📂 Article 📅 1992 🏛 Springer US 🌐 English ⚖ 713 KB

The effects of altered extracellular K+ concentrations ([K+]o) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a potent class III antiarrhythmic agent, were examined in isolated guinea-pig ventricular papillary muscle. At a normal [K+]o (4 mM) and at CL