✦ LIBER ✦
Differential Pulse Voltammetric Determination of Local Anesthetics Heptacaine, Carbisocaine and Pentacaine at DNA Modified Screen-Printed Electrode
✍ Scribed by M. Vaníčková; E. Jakubková; M. Bučková; J. Čižmárik; J. Labuda
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 60 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1040-0397
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✦ Synopsis
Abstract
A procedure for the differential pulse voltammetric determination of three local anesthetics (Heptacaine, Carbisocaine and Pentacaine) at a screen‐printed electrode surface modified with the dsDNA layer is described. The detection limits obtained after 120 s drug accumulation from 0.01 M phosphate buffer solution pH 6.96 are 0.02 μM (Pentacaine) and 0.03 μM (Carbisocaine and Heptacaine). The method was applied to the determination of Carbisocaine in spiked serum.