Differential pulse polarographic study of the degradation of H+/K+ ATPase inhibitors SK&F 95601 and omeprazole in acidic media and the subsequent reactions with thiols

✍ Scribed by S. McClean; E. O'Kane; V.N. Ramachandran; W.F. Smyth

• Book ID: 102982284
• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 692 KB
• Volume: 292
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/0003-2670(94)00043-3

✦ Synopsis

Differential pulse polarography (DPP) has been used to monitor the degradation of benzimidazole sulphoxide antiulcer drugs SK&F 95601 and omeprazole in lop2 mol dm-3 HCl to two main products, i.e., the sulphenamide and the benzimidazole sulphide. It is also used to follow the reactions of Zmercaptoethanol with the respective products of these degradations, as simulations of their believed reactions in vivo. These reactions are also followed by UV spectrophotometry, spectrofluorimetry and liquid chromatography. DPP can also be used to selectively determine nanomolar concentrations of these antiulcer drugs and their degradation products, of value in formulation and body fluid analysis.