Annamycin (Ann) is a highly lipophilic anthracycline antibiotic that has been shown to circumvent MDR-1 both in vitro and in vivo. A liposomal formulation of Ann is currently in phase I clinical trials. The multidrug resistance-associated protein (MRP) has been found to be over-expressed in some hum
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Differential Protein Expression in the Cytosol Fraction of an MCF-7 Breast Cancer Cell Line Selected for Resistance toward Melphalan
โ Scribed by Hathout, Yetrib; Riordan, Kelly; Gehrmann, Marion; Fenselau, Catherine
- Book ID
- 126126807
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 461 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1535-3893
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In many cancer cell lines, including breast, prostate, lung, brain, head and neck, retina, and the gastrointestinal tract, opioids decrease cell proliferation in a dose-dependent and reversible manner. Opioid and/or other neuropeptide receptors mediate this decrease. We report that only the steroid-