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Differential proliferation of erythroid and granuloid spleen colonies following sublethal irradiation of the bone marrow donor

✍ Scribed by Norman S. Wolf; John J. Trentin

Book ID
102308422
Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
356 KB
Volume
75
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Spleen colonies produced by sublethally irradiated mouse bone marrow cells were compared to those produced by unirradiated marrow cells in lethally irradiated mice. Sublethally irradiated marrow cells gave rise to many fewer spleen colonies. At seven days of colony age, the ratio of erythroid colonies to granuloid colonies was lower (< 1) than for colonies formed by unirradiated marrow (2 to 3 or more). Delay of harvest of colonies to day 10 or 12 resulted in 6 to 11 fold increase in the ratio of erythroid to granuloid colonies due largely to the belated appearance of erythroid colonies.

πŸ“œ SIMILAR VOLUMES

Distribution and identity of the earlies
Distribution and identity of the earliest proliferating progeny of colony-forming cells in regenerating murine spleen and bone marrow
✍ Wolf, Norman ;Rosse, Cornelius πŸ“‚ Article πŸ“… 1982 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 889 KB

## Abstract A study was made of the sites of development and the types of cells found in very early hemopietic colomes in the mouse spleen. Two, 3, and 4 days after transplantation, the proliferating descendants of transplanted bone‐marrow cells were identified on radioautographs of spleen sections