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Differential Production of IL-12, IFN- , and IFN- by Mouse Dendritic Cell Subsets

✍ Scribed by Hochrein, H.; Shortman, K.; Vremec, D.; Scott, B.; Hertzog, P.; O'Keeffe, M.


Book ID
121743691
Publisher
American Association of Immunologists
Year
2001
Tongue
English
Weight
886 KB
Volume
166
Category
Article
ISSN
0022-1767

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Phytohemagglutinin (PHA)-derived T lymphoblasts or T cell clones from patients genetically deficient in IL-12R g 1 (IL-12R g 1 -/-) or IFN-+ R1 (IFN-+ R1 -/-) produced two-to threefold reduced IFN-+ levels compared to the corresponding cells from healthy individuals after anti-CD3 and PMA stimulatio