We have studied modulation of purinergic receptors (P(2Y) and P(2X) subtypes) on changes in intracellular Ca(2+) [Ca(2+)](i) and expression and production of COX-2 in human microglia. Measurements using Ca(2+)-sensitive spectrofluorometry showed adenosine triphosphate (ATP) to cause rapid transient
✦ LIBER ✦
Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation
✍ Scribed by Nobuko Ishiura; Hiroko Nakashima; Rei Watanabe; Yoshihiro Kuwano; Takahiro Adachi; Yoshimasa Takahashi; Takeshi Tsubata; Hitoshi Okochi; Kunihiko Tamaki; Thomas F. Tedder; Manabu Fujimoto
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 577 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0014-2980
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## Abstract T cell receptor (TCR) signal transduction is mediated by the immunoreceptor tyrosine‐based activation motifs (ITAM). The ten ITAM in the TCR complex are distributed in two distinct signaling modules termed TCR ζζ and CD3 γϵ/δϵ. To delineate the specific role of the ζ ITAM in T cell deve