In vivo transgenic mutation assays
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John A. Heddle; Stephen Dean; Takehiko Nohmi; MichaΓ«l Boerrigter; Daniel Cascian
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Article
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2000
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John Wiley and Sons
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English
β 71 KB
Transgenic rodent gene mutation models provide quick and statistically reliable assays for mutations in the DNA from any tissue. For regulatory applications, assays should be based on neutral genes, be generally available in several laboratories, and be readily transferable. Five or fewer repeated t