Differential modulation of cyclin-dependent kinase inhibitor p27Kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40

Vascular smooth muscle cell-specific reg

Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21WAF1/Cip1 transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21WAF1/Cip1 promoter

✍ Mary M. Kavurma; Levon M. Khachigian 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 323 KB 👁 1 views

## Abstract Smooth muscle cells (SMC) play a central role in common vascular pathologies such as atherosclerosis and restenosis. Understanding the molecular regulation of SMC proliferation at a transcriptional level may provide important clues for the targeted control of vascular hyperplasia. We re