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Differential modulation of base excision repair activities during brain ontogeny: Implications for repair of transcribed DNA

โœ Scribed by Ella W. Englander; Huaxian Ma


Book ID
113775893
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
261 KB
Volume
127
Category
Article
ISSN
0047-6374

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Endogenous oxidative damage to brain mitochondrial DNA and consequential disturbances of gene expression and mitochondrial dysfunction have long been implicated in aging and the pathogenesis of neurodegenerative diseases. It has yet to be determined, however, whether mitochondria in brain cells cont