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Differential modulation of 5-hydroxytryptamine1D binding sites by GTP a and GTPgammaS

✍ Scribed by Melissa A. Harrington; Stephen J. Peroutka

Book ID
115800972
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
302 KB
Volume
506
Category
Article
ISSN
0006-8993

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Identification of 5-hydroxytryptamine1D
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✍ Stephen J. Peroutka; Julie A. Switzer; Anne Hamik πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 653 KB

High-affinity, specific 3H-5-hydroxytryptamine (5-HT) binding was analyzed in membrane homogenates of human frontal cortex, caudate, and globus pallidus. 5-HT1A and 5-HT1C binding sites were pharmacologically blocked using 100 nM 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-OH-DPAT) and 100 nM mesulerg