## One of the most serious complications faced by patients with inflammatory bowel disease (IBD) is the potential development of colorectal cancer (CRC). There is a compelling need to enhance the accuracy of cancer screening of IBD patients. MicroRNAs (miRNAs) are small nonprotein-coding RNAs that
Differential MicroRNA expression tracks neoplastic progression in inflammatory bowel disease-associated colorectal cancer
β Scribed by Ziad Kanaan; Shesh N. Rai; M. Robert Eichenberger; Christopher Barnes; Amy M. Dworkin; Clayton Weller; Eric Cohen; Henry Roberts; Bobby Keskey; Robert E. Petras; Nigel P.S. Crawford; Susan Galandiuk
- Book ID
- 112099726
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 77 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1059-7794
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Background: Patients with inflammatory bowel disease (IBD) are at increased risk of developing colorectal cancer. Aberrant microRNA (miR) expression has been linked to carcinogenesis; however, no reports document a relationship between IBD-related neoplasia (IBDN) and altered miR expression. In the
Background: Inflammatory bowel disease (IBD) exposes patients to an increased risk of colorectal cancer (i-CRC) and differences between i-CRC and sporadic colorectal cancer (s-CRC) pathogenesis were reported. In s-CRC, studies indicate abnormalities in the tumor-suppressor gene Cdx2. This study comp