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Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins

✍ Scribed by Araceli Rosa; Marco M. Picchioni; Sridevi Kalidindi; Caroline S. Loat; Joanne Knight; Timothea Toulopoulou; Ronald Vonk; Astrid C. van der Schot; Willem Nolen; René S. Kahn; Peter McGuffin; Robin M. Murray; Ian W. Craig

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 96 KB
Volume: 147B
Category: Article
ISSN: 1552-4841
DOI: 10.1002/ajmg.b.30616

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## Abstract A pair of female monozygotic (MZ) twins, heterozygous carriers for a deletion in the DMD gene and discordant for the clinical manifestations of Duchenne muscular dystrophy, were analyzed by molecular studies, in situ hybridization, and methylation pattern of X chromosomes to search for