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Differential Ligand Recognition by the Src and Phosphatidylinositol 3-Kinase Src Homology 3 Domains: Circular Dichroism and Ultraviolet Resonance Raman Studies †

✍ Scribed by Okishio, Nobuyuki; Tanaka, Toshiyuki; Fukuda, Ryuji; Nagai, Masako


Book ID
125960650
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
195 KB
Volume
42
Category
Article
ISSN
0006-2960

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Interactions of phosphatidylinositol 3-k
✍ Nobuyuki Okishio; Masako Nagai; Ryuji Fukuda; Shigenori Nagatomo; Teizo Kitagawa 📂 Article 📅 2000 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 221 KB 👁 1 views

Absorption, circular dichroism (CD), and UV resonance Raman (UVRR) spectroscopies were applied to selectively examine the environmental and structural changes of Trp and Tyr residues in the phosphatidylinositol 3-kinase (PI3K) SH3 domain induced by ligand association. Comparison of the spectra of PI