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Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal

✍ Scribed by Renee M.Y Barge; Roel Willemze; Peter Vandenabeele; Walter Fiers; Rudi Beyaert


Book ID
117107640
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
321 KB
Volume
409
Category
Article
ISSN
0014-5793

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## Abstract Inhibition of histone deacetylase (HDAC) is a novel strategy for the treatment of leukemias via restoration of aberrantly silenced genes. In this study, we conducted a detailed analysis of anti‐leukemic effects of an HDAC inhibitor (HDI), depsipeptide (FK228), using myeloid leukemia cel