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Differential Interaction of Tubulin Isotypes with the Antimitotic Compound IKP-104 †

✍ Scribed by Khan, Israr A.; Tomita, Isao; Mizuhashi, Fukutaro; Ludueña, Richard F.


Book ID
126975073
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
307 KB
Volume
39
Category
Article
ISSN
0006-2960

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Microtubules and actin filaments are two of the major components of the cytoskeleton. There is accumulating evidence for interaction between the two networks. Both the ␣and ␤-subunits of tubulin exist as numerous isotypes, some of which have been highly conserved in evolution. In an effort to better