Differential Inhibition of Invasion and Proliferation by Bisphosphonates: Anti-Metastatic Potential of Zoledronic Acid in Prostate Cancer
โ Scribed by Richard Montague; Claire A Hart; Nicholas J George; Vijay A.C Ramani; Michael D Brown; Noel W Clarke
- Book ID
- 113608677
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 599 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0302-2838
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## Abstract Zoledronic acid (ZOL) has proved activity in bone metastases from prostate cancer through inhibition of mevalonate pathway and of prenylation of intracellular proteins. We have reported that ZOL synergizes with R115777 farnesyltransferase inhibitor (FTI, Zarnestra) in inducing apoptosis