Differential inhibition of dihydrofolic reductase from different species
β Scribed by B. R. Baker; Beng-Thong Ho
- Publisher
- John Wiley and Sons
- Year
- 1964
- Tongue
- English
- Weight
- 165 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-3549
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We have investigated the importance of polarization by the enzyme dihydrofolate reductase (DHFR) on its substrates, folate and dihydrofolate, using a series of quantum mechanical (QM) techniques (Hartree-Fock (HF), MΓΈller-Plesset second-order perturbation theory (MP2), local density approximation (L
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