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Differential inhibition by TAK-044 of the inotropic effects of endothelin-1 and endothelin-3

โœ Scribed by Shin-ichi Yomogida; Jun Maruya; Ikuo Norota; Kuniaki Ishii; Masao Endoh


Book ID
113584683
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
513 KB
Volume
492
Category
Article
ISSN
0014-2999

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Pharmacological characteristics of endot
โœ Ikuo Norota; Masao Endoh ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer ๐ŸŒ English โš– 754 KB

Endothelin-3 (ET-3) elicited a concentration-dependent positive inotropic effect on rabbit papillary muscle, the maximal response being approximately 65% of the maximal response to isoproterenol. ET-1 induced a positive inotropic effect over the concentration range below 10(-9) M, at which ET-3 did