Differential induction of stromelysin mRNA by bovine articular chondrocytes treated with interferon-γ and interleukin-1α

✍ Scribed by J. C. Quintavalla; R. A. Berg; A. J. Beavis; S. P. Piccoli; J. J. Rediske; M. Kurkinen; R. A. Patrick; F. M. Robertson

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 1001 KB
• Volume: 154
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1041540114

✦ Synopsis

Articular chondrocytes from rheumatoid joints have been shown to express class II major histocompatibility (MHC) antigens that were correlated with the presence of interferon-gamma (IFN-y) in the inflamed joint. Chondrocytes expressing MHC antigen5 function as antigen presenting cells and thus stimulate lymphocyte proliferation. These responses suggest a powerful role for the IFN-y stimulation of chondrocytes. The present studies were designed to examine the functional role of chondrocytes exposed to IFN-y during cartilage degradation that occurs in synovial disease. Destruction of cartilage in arthritis is partially attributable to metalloproteinases released by the chondrocytes in response to interleukin-I (IL-I 1.